Soo‐Yeon Yang, Seung A Chae, Won Yeong Bang, Minjee Lee, O‐Hyun Ban, Soo‐Jung Kim, Young Hoon Jung and Jungwoo Yang. Anti‐infammatory potential of Lactiplantibacillus plantarum IDCC 3501 and its safety evaluation. Brazilian Journal of Microbiology. 52: 2299 - 2306 (2021)

This study investigated the anti-infammatory activity of Lactiplantibacillus plantarum IDCC 3501 isolated from kimchi (Korean fermented food) and its safety. When lipopolysaccharide (LPS)-induced RAW 264.7 macrophages were treated with cell-free supernatant from L. plantarum IDCC 3501, the mRNA expression level of infammatory markers (i.e., TNF-α, IL-1β, and IL-6) was signifcantly reduced. In addition, the decreased cell viability by LPS was recovered and NO production in LPS-induced cell was also decreased. For the safety assessment, the genes responsible for antibiotic resistance and virulence were not detected from the genome analysis of this strain. Consistent with this, minimal inhibitory concentrations against various antibiotics, biogenic amines, and d-lactate production, as well as enzymatic and hemolysis activities, indicated that L. plantarum IDCC 3501 did not produce any harmful compounds during fermentation. Furthermore, no acute toxicity and mortality were observed in a murine mouse model. Based on our fndings, L. plantarum IDCC 3501 is safe and benefcial for human consumption.